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1. Departing to Des Moines

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Flights > Des Moines Flights > Lexington to Des Moines Flights

Book Lexington to Des Moines Flights on Trip.com

First | Business class | Economy class | Direct

Search for cheap flights from Lexington to Des Moines on Trip.com. Trip.com provides the best real-time Lexington to Des Moines airfares and flight deals available, featuring advanced flight planning tools like FareAlerts, DealFinder fare calendars and Lexington Flight + Hotel deals that make a Des Moines holiday or Des Moines tour more convenient and affordable.

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