Worldwide Coverage
Worldwide Coverage
Flights to over 5,000 cities
One-stop Service Guarantee
One-stop Service Guarantee
Price guaranteed upon confirmed payment, booking guaranteed once tickets issued
Secure Payment
Secure Payment
Convenient & reliable booking and payment system

Find Madrid to Santiago del Estero flights starting at CAD 902.

Book one-way or return flights from Madrid to Santiago del Estero from as little as CAD 902. Choose from the popular airlines below and book your flight today!

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Searching for the best last minute flight from Madrid to Santiago del Estero? Find one-way or return flights that are affordable and fit your itinerary.

Trip.com monitors the ticket fares of flights from Madrid to Santiago del Estero. Stay updated on price trends and snag the best deals for your upcoming trip.

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Find Cheapest Airlines Flying from Madrid to Santiago del Estero

View airlines operating flights from Madrid to Santiago del Estero. Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

Aerolineas Argentinas
From CAD 902
ITA Airways
From CAD 1,145
Air Europa
From CAD 1,284
Avianca
From CAD 1,426
Boliviana De Aviación
From CAD 1,631
Iberia
From CAD 1,857
LATAM Airlines
From CAD 1,892
Ethiopian Airlines
From CAD 1,974
Air France
From CAD 2,249
ANA airlines

Find more flights and airlines

Alternative Routes for Madrid to Santiago del Estero Flights

Discover different routes, airlines, and transfers and find the best alternative flights for your journey from Madrid to Santiago del Estero.

  • Cheapest
    Aerolineas Argentinas
    MAD
    09:30
    33h 40m
    1 transfer
    SDE
    14:10
    Madrid Barajas Airport - Santiago Del Estero Airport
    Tue, Jul 16Aerolineas Argentinas
    CAD 902
  • Aerolineas Argentinas
    MAD
    09:30
    33h 40m
    1 transfer
    SDE
    14:10
    Madrid Barajas Airport - Santiago Del Estero Airport
    Tue, Jul 16Aerolineas Argentinas
    CAD 902
    Find More Flights

How do I find the cheapest flights?

  • When are flight tickets from Madrid (MAD) to Santiago del Estero (SDE) the cheapest?

    Airlines adjust prices for flights from Madrid to Santiago del Estero based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the cheapest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much are flights from Madrid (MAD) to Santiago del Estero (SDE) cost?

    According to Trip.com's data, the lowest price is around CAD 2,420.
  • What is the transportation method from the main airport to downtown in Santiago del Estero?

    • The distance from Santiago Del Estero Airport to downtown is about 4km, by taxi about 20 minutes.
  • How many airports in Santiago del Estero (SDE)?

    There are 1 airport(s) in Santiago del Estero (SDE): Santiago Del Estero Airport.

How to find a cheap flight from Madrid to Santiago del Estero

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Madrid to Santiago del Estero. Book your flights at the right time and save more.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com
Flight Information for Madrid to Santiago del Estero Flights

Cheapest direct flight price

CAD 902

Cheapest month

April

Peak season for travel

February

Flight distance

9,837.67km

Popular airline

Avianca