App
Customer Support
CAD
Find Bookings
Worldwide Coverage
Worldwide Coverage
Flights to over 5,000 cities
One-stop Service Guarantee
One-stop Service Guarantee
Price guaranteed upon confirmed payment, booking guaranteed once tickets issued
Secure Payment
Secure Payment
Convenient & reliable booking and payment system

Find Mayaguez to Santo Domingo flights starting at CAD 3,055.

We've found these cheap flights for you. You can book one-way or return flight tickets.

  • Round-trip
      • MAZ13:25
        35h 34m
        2 stops
        SDQ00:59
        Sat, Feb 1|Mayaguez - Santo Domingo|United Airlines
        SDQ09:00
        30h 49m
        2 stops
        MAZ15:49
        Fri, Feb 7|Santo Domingo - Mayaguez|Jetblue Airways
        CAD 3,055CAD 3,357
        9% OFF
        9% OFF
        CAD 3,357CAD 3,055

        Choose United Airlines flights from Mayaguez to Santo Domingo. The one-way connecting flight with United Airlines departs from Eugenio M. De Hostos Airport on Sat, Feb 1-Fri, Feb 7, arriving at Las Américas International Airport. One-way Prices start from CAD 3,055 including taxes and charges.

      • MAZ01:00 pm
        3h 5m
        Nonstop
        SDQ02:00 pm
        Mon, Jan 13|Mayaguez - Santo Domingo|United Airlines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to fly from Mayaguez to Santo Domingo?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Alternative Routes for Mayaguez to Santo Domingo Flights

Searching for potential routes that might be cheaper and faster? Check out these alternative flights from Mayaguez to Santo Domingo.

  • Cheapest
    United Airlines
    MAZ
    13:25
    35h 34m
    4 transfer
    SDQ
    00:59
    Eugenio M. De Hostos Airport - Las Américas International Airport
    Sat, Feb 1United Airlines
    CAD 3,055
  • United Airlines
    MAZ
    13:25
    35h 34m
    4 transfer
    SDQ
    00:59
    Eugenio M. De Hostos Airport - Las Américas International Airport
    Sat, Feb 1United Airlines
    CAD 3,055
    Find More Flights

FAQ

  • When are flight tickets from Mayaguez (MAZ) to Santo Domingo (SDQ) the cheapest?

    Airlines adjust prices for flights from Mayaguez to Santo Domingo based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the cheapest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much are flights from Mayaguez (MAZ) to Santo Domingo (SDQ) cost?

    According to Trip.com's data, the lowest price is around CAD 765.

  • What is the transportation method from the main airport to downtown in Santo Domingo?

    • The distance from Las Américas International Airport to downtown is about 33km, by taxi about 50 minutes.
    • The distance from La Isabela International Airport to downtown is about 8km, by taxi about 20 minutes.

  • How many airports in Santo Domingo (SDQ)?

    There are 2 airport(s) in Santo Domingo (SDQ): La Isabela International Airport and Las Américas International Airport.

How to find a cheap flight from Mayaguez to Santo Domingo

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Mayaguez to Santo Domingo. Book your flights at the right time and save more.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com

Flight Information for Mayaguez to Santo Domingo Flights

Off-season travel monthOctober
Peak season for travelDecember
Flight distance291.31km
Popular airlineUnited Airlines

Contact Us

About

Other Services

Payment Methods
Our Partners
Copyright © 2025 Trip.com Travel Singapore Pte. Ltd. All rights reserved
Site Operator: Trip.com Travel Singapore Pte. Ltd.