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Find Panama City to Santa Cruz flights starting at CAD 212.

Book one-way or return flights from Panama City to Santa Cruz from as little as CAD 212. Choose from the popular airlines below and book your flight today!

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Searching for the best last minute flight from Panama City to Santa Cruz? Find one-way or return flights that are affordable and fit your itinerary.

Trip.com monitors the ticket fares of flights from Panama City to Santa Cruz. Stay updated on price trends and snag the best deals for your upcoming trip.

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Find Cheapest Airlines Flying from Panama City to Santa Cruz

View airlines operating flights from Panama City to Santa Cruz. Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

Avianca
From CAD 212
Copa Airlines
From CAD 463
United Airlines
From CAD 807
American Airlines
From CAD 896
ANA airlines

Find more flights and airlines

Alternative Routes for Panama City to Santa Cruz Flights

Discover different routes, airlines, and transfers and find the best alternative flights for your journey from Panama City to Santa Cruz.

  • Cheapest
    Avianca
    PTY
    17:40
    7h 20m
    1 transfer
    VVI
    02:00
    Tocumen International Airport - Viru Viru International Airport
    Wed, May 1Avianca
    CAD 212
  • Avianca
    PTY
    17:40
    7h 20m
    1 transfer
    VVI
    02:00
    Tocumen International Airport - Viru Viru International Airport
    Wed, May 1Avianca
    CAD 212
    Find More Flights

How do I find the cheapest flights?

  • When are flight tickets from Panama City (PTY) to Santa Cruz (SRZ) the cheapest?

    Airlines adjust prices for flights from Panama City to Santa Cruz based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the cheapest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much are flights from Panama City (PTY) to Santa Cruz (SRZ) cost?

    According to Trip.com's data, the lowest price is around CAD 582.
  • How long is the flight from Panama City (PTY) to Santa Cruz (SRZ)?

    It takes about 5 hours to fly from Panama City (PTY) to Santa Cruz (SRZ).
  • What is the transportation method from the main airport to downtown in Santa Cruz?

    • The distance from Viru Viru International Airport to downtown is about 17km, by taxi about 30 minutes.
  • What are the most popular airlines that fly from Panama City (PTY) to Santa Cruz (SRZ)?

    Airlines with flights from Panama City (PTY) to Santa Cruz (SRZ): Copa Airlines and United Airlines.
  • What's the most popular airline for direct flights from Panama City (PTY) to Santa Cruz (SRZ)?

    Copa Airlines operates 1 direct flights from Panama City (PTY) to Santa Cruz (SRZ).
  • How many airports in Santa Cruz (SRZ)?

    There are 2 airport(s) in Santa Cruz (SRZ): El Trompillo Airport and Viru Viru International Airport.

How to find a cheap flight from Panama City to Santa Cruz

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Panama City to Santa Cruz. Book your flights at the right time and save more.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com
Flight Information for Panama City to Santa Cruz Flights

Cheapest direct flight price

CAD 212

Cheapest return ticket price

CAD 583

Cheapest month

March

Peak season for travel

October

Flight distance

3,476.98km

Average flight time

5 hours

Popular airline

Avianca