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Mcghee Tyson Airport to Buffalo Niagara International Airport flight

Explore the cheapest one-way and round-trip flights from Mcghee Tyson Airport to Buffalo Niagara International Airport over the next 90 days, with one-way fares from US$183 and round-trip from US$242. Based on Trip.com's latest 7-day flight data.

    • Cheapest
      TYS 18:17
      5h 47m
      1 stop
      BUF 00:04
      Knoxville - Buffalo | Sun, Dec 6 | Delta Air Lines
      US$183 US$321
      43% off
      43% off
      US$321 US$183
    • TYS 18:26
      5h 28m
      1 stop
      BUF 23:54
      Knoxville - Buffalo | Sun, Dec 6 | American Airlines
      US$185 US$321
      42% off
      42% off
      US$321 US$185
    • TYS 18:07
      5h 52m
      1 stop
      BUF 23:59
      Knoxville - Buffalo | Wed, Nov 25 | Delta Air Lines
      US$187 US$321
      42% off
      42% off
      US$321 US$187
    • TYS 10:33
      6h 29m
      1 stop
      BUF 17:02
      Knoxville - Buffalo | Thu, Nov 26 | United Airlines
      US$190
      41% off
      US$321 US$190
    • TYS 06:45
      5h 45m
      1 stop
      BUF 12:30
      Knoxville - Buffalo | Thu, Nov 26 | Hahn Air
      US$196
      39% off
      US$321 US$196
    • TYS 17:01
      6h 38m
      1 stop
      BUF 23:39
      Knoxville - Buffalo | Tue, Nov 24 | American Airlines
      US$205
      36% off
      US$321 US$205
    • TYS 18:13
      5h 52m
      1 stop
      BUF 00:05
      Knoxville - Buffalo | Wed, Nov 25 | American Airlines
      US$213
      34% off
      US$321 US$213
    • TYS 05:40
      5h 26m
      1 stop
      BUF 11:06
      Knoxville - Buffalo | Thu, Nov 26 | Delta Air Lines
      US$218
      32% off
      US$321 US$218
    • TYS 06:20
      4h 22m
      1 stop
      BUF 10:42
      Knoxville - Buffalo | Sun, Dec 6 | United Airlines
      US$229
      28% off
      US$321 US$229
    • TYS 13:00
      17h 25m
      1 stop
      BUF 14:00
      Knoxville - Buffalo | Tue, Oct 27 | Normal Airline
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    • TYS 12:42
      5h 54m
      1 stop
      BUF 18:36
      Knoxville - Buffalo | Fri, Nov 27 | American Airlines
      BUF 18:58
      3h 50m
      1 stop
      TYS 22:48
      Buffalo - Knoxville | Thu, Dec 3 | American Airlines
      US$242 US$409
      41% off
      41% off
      US$409 US$242
    • TYS 05:40
      5h 36m
      1 stop
      BUF 11:16
      Knoxville - Buffalo | Fri, Nov 27 | Delta Air Lines
      BUF 12:00
      5h 59m
      1 stop
      TYS 17:59
      Buffalo - Knoxville | Thu, Dec 3 | Delta Air Lines
      US$246 US$409
      40% off
      40% off
      US$409 US$246
    • TYS 07:26
      4h 9m
      1 stop
      BUF 11:35
      Knoxville - Buffalo | Sat, Nov 28 | Delta Air Lines
      BUF 06:00
      4h 20m
      1 stop
      TYS 10:20
      Buffalo - Knoxville | Thu, Dec 3 | Delta Air Lines
      US$280 US$409
      32% off
      32% off
      US$409 US$280
    • TYS 18:23
      5h 36m
      1 stop
      BUF 23:59
      Knoxville - Buffalo | Sun, Nov 29 | Delta Air Lines
      BUF 06:00
      5h 28m
      1 stop
      TYS 11:28
      Buffalo - Knoxville | Thu, Dec 3 | Delta Air Lines
      US$295
      28% off
      US$409 US$295
    • TYS 06:50
      3h 50m
      1 stop
      BUF 10:40
      Knoxville - Buffalo | Sat, Dec 5 | American Airlines
      BUF 18:58
      3h 50m
      1 stop
      TYS 22:48
      Buffalo - Knoxville | Tue, Dec 8 | American Airlines
      US$303
      26% off
      US$409 US$303
    • TYS 08:57
      6h 9m
      1 stop
      BUF 15:06
      Knoxville - Buffalo | Sat, Nov 14 | American Airlines
      BUF 19:53
      4h 2m
      1 stop
      TYS 23:55
      Buffalo - Knoxville | Tue, Nov 17 | American Airlines
      US$303
      26% off
      US$409 US$303
    • TYS 12:06
      5h 43m
      1 stop
      BUF 17:49
      Knoxville - Buffalo | Fri, Nov 13 | Delta Air Lines
      BUF 06:00
      4h 54m
      1 stop
      TYS 10:54
      Buffalo - Knoxville | Mon, Nov 16 | Delta Air Lines
      US$308
      25% off
      US$409 US$308
    • TYS 19:45
      4h 14m
      1 stop
      BUF 23:59
      Knoxville - Buffalo | Sat, Nov 14 | Delta Air Lines
      BUF 06:00
      5h 6m
      1 stop
      TYS 11:06
      Buffalo - Knoxville | Tue, Nov 17 | Delta Air Lines
      US$310
      24% off
      US$409 US$310
    • TYS 12:06
      4h 3m
      1 stop
      BUF 16:09
      Knoxville - Buffalo | Fri, Nov 20 | Delta Air Lines
      BUF 06:15
      4h 5m
      1 stop
      TYS 10:20
      Buffalo - Knoxville | Mon, Nov 23 | Delta Air Lines
      US$337
      18% off
      US$409 US$337
    • TYS 13:00
      17h 25m
      1 stop
      BUF 14:00
      Knoxville - Buffalo | Tue, Oct 27 | Normal Airline
      BUF 15:00
      6h
      Direct
      TYS 16:00
      Buffalo - Knoxville | Thu, Oct 29 | Normal Airline
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    • TYS 06:50
      3h 52m
      1 stop
      BUF 10:42
      Knoxville - Buffalo | Thu, Nov 26 | American Airlines
      US$242 US$321
      25% off
      25% off
      US$321 US$242
    • TYS 06:50
      3h 52m
      1 stop
      BUF 10:42
      Knoxville - Buffalo | Thu, Nov 26 | American Airlines
      US$264 US$872
      70% off
      70% off
      US$872 US$264
    • TYS 07:10
      4h 1m
      1 stop
      BUF 11:11
      Knoxville - Buffalo | Thu, Nov 26 | Delta Air Lines
      US$776 US$872
      11% off
      11% off
      US$872 US$776
    • TYS 07:00
      4h 5m
      1 stop
      BUF 11:05
      Knoxville - Buffalo | Sun, Dec 6 | Delta Air Lines
      US$231
      74% off
      US$872 US$231
    • TYS 06:20
      4h 22m
      1 stop
      BUF 10:42
      Knoxville - Buffalo | Sun, Dec 6 | United Airlines
      US$229
      28% off
      US$321 US$229
    • TYS 05:40
      5h 26m
      1 stop
      BUF 11:06
      Knoxville - Buffalo | Thu, Nov 26 | Delta Air Lines
      US$218
      32% off
      US$321 US$218
    • TYS 18:26
      5h 28m
      1 stop
      BUF 23:54
      Knoxville - Buffalo | Sun, Dec 6 | American Airlines
      US$185
      42% off
      US$321 US$185
    • TYS 06:45
      5h 45m
      1 stop
      BUF 12:30
      Knoxville - Buffalo | Thu, Nov 26 | Hahn Air
      US$196
      39% off
      US$321 US$196
    • TYS 18:17
      5h 47m
      1 stop
      BUF 00:04
      Knoxville - Buffalo | Sun, Dec 6 | Delta Air Lines
      US$183
      43% off
      US$321 US$183
    • TYS 13:00
      17h 25m
      1 stop
      BUF 14:00
      Knoxville - Buffalo | Tue, Oct 27 | Normal Airline
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Displayed flight fares from Knoxville to Buffalo are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Which airline offers the cheapest flights from Mcghee Tyson Airport to Buffalo Niagara International Airport?

The cheapest airline flying from Mcghee Tyson Airport to Buffalo Niagara International Airport is Delta Air Lines (from US$187) among 4 carriers operating this route. Based on Trip.com's latest 7-day flight data.

Delta Air Lines
From US$187
United Airlines
From US$190
Hahn Air
From US$196
American Airlines
From US$205

Find more flights and airlines

What is the flight schedule from Mcghee Tyson Airport to Buffalo Niagara International Airport?

Check the schedule for flights from Knoxville to Buffalo and find the flight that best matches your travel plans.

Flight info.
Departure
Arrival
Weekly Schedule

  1. AA5182

    Mcghee Tyson Airport

    09:26

    TYS

    1h 23m

    Direct

    10:49

    CLT

    - - - - - - S
    Search

  2. AA1203

    Charlotte Douglas International Airport

    09:08

    CLT

    1h 45m

    Direct

    10:53

    BUF

    S M T W T F S

  3. AA5553

    Mcghee Tyson Airport

    06:56

    TYS

    1h 24m

    Direct

    08:20

    CLT

    S M T W T F -
    Search

  4. AA1203

    Charlotte Douglas International Airport

    09:08

    CLT

    1h 45m

    Direct

    10:53

    BUF

    S M T W T F S

  5. DL1743

    Mcghee Tyson Airport

    12:00

    TYS

    1h 5m

    Direct

    13:05

    ATL

    S M T W T - S
    Search

  6. DL2266

    Hartsfield–Jackson Atlanta International Airport

    14:12

    ATL

    2h 1m

    Direct

    16:13

    BUF

    S M T W T F S

  7. UA4311

    Mcghee Tyson Airport

    05:30

    TYS

    1h 46m

    Direct

    07:16

    IAD

    S M T W T F S
    Search

  8. UA4018

    Dulles International Airport

    08:24

    IAD

    1h 22m

    Direct

    09:46

    BUF

    S - - W T - -

  9. UA4311

    Mcghee Tyson Airport

    05:30

    TYS

    1h 46m

    Direct

    07:16

    IAD

    S M T W T F S
    Search

  10. UA4248

    Dulles International Airport

    08:32

    IAD

    1h 22m

    Direct

    09:54

    BUF

    - M T - - - S

  11. DL3042

    Mcghee Tyson Airport

    19:20

    TYS

    1h 14m

    Direct

    20:34

    ATL

    S - - - - - -
    Search

  12. DL2334

    Hartsfield–Jackson Atlanta International Airport

    21:54

    ATL

    2h 5m

    Direct

    23:59

    BUF

    S M T W T F S

  13. AA5149

    Mcghee Tyson Airport

    06:00

    TYS

    2h

    Direct

    08:00

    DCA

    S M T W T F S
    Search

  14. AA4694

    Ronald Reagan Washington National Airport

    10:19

    DCA

    1h 32m

    Direct

    11:51

    BUF

    - - - - - - S

  15. DL3015

    Mcghee Tyson Airport

    05:15

    TYS

    1h 8m

    Direct

    06:23

    ATL

    S M T W T F S
    Search

  16. DL1384

    Hartsfield–Jackson Atlanta International Airport

    09:16

    ATL

    2h

    Direct

    11:16

    BUF

    S M T W T F S

  17. DL2571

    Mcghee Tyson Airport

    17:57

    TYS

    1h 8m

    Direct

    19:05

    ATL

    S M T W T - -
    Search

  18. DL2334

    Hartsfield–Jackson Atlanta International Airport

    21:54

    ATL

    2h 5m

    Direct

    23:59

    BUF

    S M T W T F S

  19. UA4581

    Mcghee Tyson Airport

    10:33

    TYS

    2h 6m

    Direct

    11:39

    ORD

    S M T W T - S
    Search

  20. UA2226

    O'Hare International Airport

    14:07

    ORD

    1h 47m

    Direct

    16:54

    BUF

    S M T W T - S
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About Mcghee Tyson Airport and Buffalo Niagara International Airport

Learn about Mcghee Tyson Airport (TYS) and Buffalo Niagara International Airport (BUF) — including location, terminals, transportation, and travel tips.

Flight distance 912.98km
Cheapest one-way ticket price US$183
Cheapest return ticket price US$242

FAQs for Mcghee Tyson Airport to Buffalo Niagara International Airport Flights

  • What are the cheapest flights from Mcghee Tyson Airport to Buffalo Niagara International Airport?

    One-way flights from Mcghee Tyson Airport to Buffalo Niagara International Airport currently start from US$183, and round-trip fares start from US$242. The current lowest fare is a Delta Air Lines flight departing on Sun, Dec 6; prices may vary depending on availability.
  • Based on Trip.com flight data for departures within the next 30 days with at most one stop, the average one-way price from Mcghee Tyson Airport to Buffalo Niagara International Airport is US$232. Prices may vary depending on the departure date, airline, and availability.
  • Enter Mcghee Tyson Airport and Buffalo Niagara International Airport, select your departure date and number of passengers, then compare flights by price, flight duration, and baggage allowance. Once you've chosen a fare, review the change and refund rules, fill in passenger details, and pay to receive your booking confirmation.

Find Cheap Flights with Trip.com

Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

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Prices displayed on this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, Wi-Fi, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within the last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

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To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.